The team collected large-scale datasets of cellular biomolecules’ expression profiles upon Akt2-specific activation. They combined the data to get a unified view of the molecular networks regulated by ...

Researchers present novel therapeutics that rejuvenate a previously undruggable mitochondrial regulator of aging through a new mode of enzyme activation. Disclaimer: AAAS and EurekAlert! are not ...

A multicolored 3D model of an enzyme binding double-stranded DNA against a light purple background Computational enzyme design could allow for reactions not seen in nature. Credit: Ian Haydon ...

This method allows specific delivery of anti-cancer prodrugs to tumor cells using affibody conjugation, to avoid unwanted off-target effects and increase the time between drug doses. Antibody-directed ...

Traditionally developed antibiotics generally act inhibiting essential bacterial enzymes. However, new strategies are urgently needed to discover novel antibiotics against bacterial infections, such ...

Researchers have found a way to trap telomerase, the enzyme cancer cells rely on for endless division, in a stalled and non-productive state. The discovery, published in Nature Communications, used ...

A new preclinical study found that inhibiting the enzyme LSD1 can activate the skin’s immune system and suppress tumor growth ...