CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR ...

Even gene drives aimed at controlling malaria-carrying mosquitoes rely on CRISPR’s precision. Among CRISPR’s many variants, the compact Type V Cas12 enzymes—key players in genome editing, diagnostics, ...

In nature, the best-known CRISPR system, CRISPR-Cas9, cuts any RNA or DNA it recognizes as foreign, and thereby protects bacteria from viral attacks. Another CRISPR system, one that is relatively ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms. The ...

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how ...

Turning genes on and off is like flipping a light switch, controlling whether genes in a cell are active. When a gene is ...

Gene editing in plants remains challenging, with the traditional non-homologous end-joining (cNHEJ) repair pathway often ...

Previously unmapped sections of the genome explain how cells sense their mechanical environment and could open new paths for ...

(Nanowerk News) The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness ...

CRISPR-Cas is an adaptive immune system of prokaryotes (bacteria and archaea). Apart from protecting its host against invading viruses, alternative biological functions of CRISPR-Cas have also been ...

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to protect ...