To completely understand the interaction of CYP2D6 and tamoxifen effectiveness, future research should be directed at some critically important, but, understudied areas. First, a comprehensive ...

October 7, 2009 — More data are available to support the use of a genetic test to predict a woman's response to tamoxifen, so that those who will not respond can be offered alternative therapies. The ...

Functional Activity of the OCT-1 Protein Is Predictive of Long-Term Outcome in Patients With Chronic-Phase Chronic Myeloid Leukemia Treated With Imatinib Evidence has emerged that the clinical benefit ...

In recent years, scientists discovered that an enzyme called CYP2D6 could possibly predict whether a patient would respond to the drug. Small studies aimed at confirming the predictive link, however, ...

We absolutely agree with the authors' statement that large, well-designed clinical trials would support genotype-guided tamoxifen administration. However, ideally one should adopt a genotyping ...

Suicide completion, 1 lifetime history of suicide attempts, 2 suicidal risk 3 and the severity of the objective circumstances related to the suicide attempt 4 have been found to be more likely in ...