The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...
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Calcium-induced release identified as key driver of dangerous muscle disorders
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium ...
Excitation–contraction (EC) coupling in skeletal muscle depends upon trafficking of CaV1.1, the principal subunit of the dihydropyridine receptor (DHPR) (L-type Ca²⁺ channel), to plasma membrane ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 12 (Jun. 5, 2001), pp. 6935-6940 (6 pages) To investigate the molecular basis of the voltage sensor that ...
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