We have used luminescence resonance energy transfer between regulatory light chains (RLC) to detect structural changes within the dimeric myosin molecule in contracting muscle fibers. Fully functional ...

At the molecular level, muscle contraction is defined by myosin molecules pulling actin filaments. New electron cryomicroscopy images with unprecedented resolution taken by researchers at Osaka ...

In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of ...

Our present understanding of the mechanism of contraction is based on fundamental discoveries, all of which arose from studies on striated muscle as the early biochemists and physiologists became ...

The actin and myosin complex (actomyosin) generates contraction force of a muscle utilizing the adenosine triphosphate (ATP) hydrolysis reaction. Many attempts have thus been made to explain the ...

Muscle contraction is the tightening, shortening, or lengthening of muscles when you do some activity. It can happen when you hold or pick up something, or when you stretch or exercise with weights.

Researchers have shed light on the molecular mechanisms underlying hibernation, publishing their findings today as a Reviewed Preprint in eLife. Their research, in small and large hibernating mammals, ...

Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ...

Most of us will probably be able to recall at least vaguely that a molecule called ATP is essential for making our bodies move, but this molecule is only a small part of a much larger system. Although ...

Atomic images of muscle molecules in action have now been captured by researchers, giving possibility of new nanomachines. At the molecular level, muscle contraction is defined by myosin molecules ...