One can assume that the schedule changes had something to do with the records of each team. The Buccaneers and 49ers both have 3-1 records, while the Patriots and Saints are a combined 2-6. The Saints are one of just two teams that are 0-4.

NFL Week 5 betting spreads, lines, point totals for every game on the NFL Week 5 schedule, with odds for favorites and underdogs in each NFL matchup.

It's a brutal blow for the Giants to lose their star wide receiver at any time, but especially so in Week 4, as rookie quarterback Jaxson Dart makes his NFL debut. Nabers had two catches for 20 receiving yards prior to his exit, going down on a deep shot from Dart near the end zone.