A mixture of DNA and proteins—known as "chromatin"—sits inside every cell nucleus as a jumbled puddle of genetic information. As cells prepare to divide during mitosis, the chromatin is condensed into ...

Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precision and ...

This valuable study analyzes aging-related chromatin changes through the lens of intra-chromosomal gene correlation length, which is a novel computational metric that captures spatial correlations in ...