Week 11 brought plenty of stunners, including the Jacksonville Jaguars routing the Los Angeles Chargers and the Bo Nix-led Denver Broncos outdueling the Kansas City Chiefs. Now we've got another slate full of intriguing action in Week 12.

Week 12 of the 2025 NFL season kicks off on Thursday night when the Buffalo Bills visit the Houston Texans and wraps up Monday night with Christian McCaffrey's San Francisco 49ers facing off against the tailback's former franchise, the Carolina Panthers.

Here we will look at and discuss some predictions, odds, picks for the NFL Week 12 game between the 49ers and the Panthers.

The Jets are giving up a staggering 130.9 yards on the ground per game and allowing more than one touchdown to opposing running backs each game. A dual-threat running back could torch this defense, as we saw from TreVeyon Henderson last week.

NFL Week 12 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Atlanta Falcons and New Orleans Saints.

Two teams that are currently leading their divisions face off in an intraconference matchup in Week 12. The Pittsburgh Steelers hit the road to face the Chicago Bears as we continue our NFL odds series with a Steelers-Bears prediction and pick.