The problem of global optimization is pivotal in a variety of scientific fields. Here, we present a robust stochastic search method that is able to find the global minimum for a given cost function, ...

Cellular dynamics are intrinsically noisy, so mechanistic models must incorporate stochasticity if they are to adequately model experimental observations. As well as intrinsic stochasticity in gene ...

Multistate Markov models are frequently used to characterize disease processes, but their estimation from longitudinal data is often hampered by complex patterns of incompleteness. Two algorithms for ...