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Calcium-induced release identified as key driver of dangerous muscle disorders
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium ...
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Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction
The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium ...
Heart failure is a pressing worldwide public-health problem with millions of patients having worsening heart failure. Despite all the available therapies, the condition carries a very poor prognosis.
Inherited metabolic diseases are rare monogenic conditions that disrupt biochemical pathways, affecting energy production and ...
Ian Burkhart was on holiday with friends in 2010 when his life changed forever. He dived into shallow water and broke his neck, leaving him paralysed from the shoulders down at the age of 19. “At that ...
(β-ARs) regulate cardiac function during sympathetic nerve stimulation. β-ARs are present in both the cardiac T-tubule (TTM) and outer surface membrane (OSM), but how their location impacts their ...
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