When a sperm meets an egg, a lot has to go right for an embryo to develop into a complete organism. One critical step of ...
When a key protein regulator dials down DNA repair mechanisms, our cells accumulate more mutations, which may cause us to age faster ...
Targeted DNA editing by CRISPR technology has great potential for applications in biotechnology and gene therapy. However, precise gene editing remains a challenge largely due to insufficient control ...
The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...
Up to 5% of patients with metastatic castration-resistant prostate cancer (mCRPC) harbour loss-of-function alterations in mismatch repair genes (dMMR) resulting in microsatellite instability (MSI-H).
Twenty-one pathogenic variants found in clinically relevant genes, with an enrichment in mismatch repair genes. HealthDay News — Mismatch repair (MMR) germline alterations are enriched among patients ...
We present a case of a 65-year-old woman with a history of kidney and pancreas transplants for type 1 diabetes mellitus who presented with small bowel obstruction and was found to have a poorly ...
Johnia Berry, 21, was stabbed more than 20 times in her Knoxville apartment. University of Tennessee graduate student Johnia Berry was brutally stabbed to death in her Knoxville apartment in 2004, in ...
Summary: Microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) drive genomic instability in several aggressive tumor types. Cancers exhibiting MSI-H or dMMR phenotypes accumulate ...
This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...
NEW YORK – GlaxoSmithKline's checkpoint inhibitor Jemperli (dostarlimab) spared 80 percent of patients with earlier-stage solid tumors characterized by mismatch repair deficiency (dMMR) from needing ...
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