In a new study published in the Open Access journal Viruses, researchers demonstrate how the use of the gene editing tool TALENs reduces the presence of key viral proteins in cell culture and animals models of Hepatitis B infection. The researchers from the University of the Witwatersrand, South Africa, engineered TALEN-encoding mRNA coated in lipid nanoparticles to target viral core proteins surface proteins. Administration resulted in a reduction of these viral proteins. This reduction indicat
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A new study published in the Open Access journal Genes by researchers from Boston University shows how PAX3, a key regulatory protein, is involved in the development of melanoma, an advanced type of skin cancer. The researchers developed a novel computer programme which they used to identify regions of DNA in which PAX3 binds, highlighting exactly how PAX3 is able to interact with melanoma DNA. These findings increase current understandings of how PAX3 regulates the development of melanoma, and
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MDPI Submission Process: Your Questions Answered
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The MDPI Achievements Report 2024 is out now. Through purposeful growth and global partnerships, MDPI is shaping the future of Open Access publishing. The report highlights areas of growth, MDPI's continued commitment to excellence, and the power of teamwork, shared goals, and international collaborations. Learn more: https://brnw.ch/21wRB7l | MDPI
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All articles in Pharmaceutics (ISSN 1999-4923) Vol 15, Issue 2, are now freely available to access, read and download: https://fal.cn/3wXzK COVER STORY: Recent advances in EVs’ extensive nanomedical drug delivery applications are presented, with special attention on red-blood-cell-derived EVs (RBCEVs). Indeed, EVs can be exploited as drug carriers owing to their advantageous properties over synthetic vehicles or nanoparticles. First, the nature and features of EVs and commonly employed methodolo
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